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Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

Author

Listed:
  • Kuang Shen

    (California Institute of Technology)

  • Sinan Arslan

    (Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign)

  • David Akopian

    (California Institute of Technology)

  • Taekjip Ha

    (Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign
    Howard Hughes Medical Institute)

  • Shu-ou Shan

    (California Institute of Technology)

Abstract

Single-molecule fluorescence microscopy techniques are used to elucidate features of the highly conserved protein-targeting machinery known as the signal recognition particle (SRP); the long SRP RNA is shown to be crucial for correct timing and precision of cargo handover to the protein-translocation machinery, a finding that could help to explain how other ribonucleosome complexes function during complex cellular processes.

Suggested Citation

  • Kuang Shen & Sinan Arslan & David Akopian & Taekjip Ha & Shu-ou Shan, 2012. "Activated GTPase movement on an RNA scaffold drives co-translational protein targeting," Nature, Nature, vol. 492(7428), pages 271-275, December.
  • Handle: RePEc:nat:nature:v:492:y:2012:i:7428:d:10.1038_nature11726
    DOI: 10.1038/nature11726
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