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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

Author

Listed:
  • Adam L. Hughes

    (Fred Hutchinson Cancer Research Center)

  • Daniel E. Gottschling

    (Fred Hutchinson Cancer Research Center)

Abstract

Vacuolar acidity in yeast is shown to decline with age, and preventing this decrease suppresses mitochondrial dysfunction and extends the lifespan of yeast.

Suggested Citation

  • Adam L. Hughes & Daniel E. Gottschling, 2012. "An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast," Nature, Nature, vol. 492(7428), pages 261-265, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7428:d:10.1038_nature11654
    DOI: 10.1038/nature11654
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    Cited by:

    1. Cierra N. Sing & Enrique J. Garcia & Thomas G. Lipkin & Thomas M. Huckaba & Catherine A. Tsang & Arielle C. Coughlin & Emily J. Yang & Istvan R. Boldogh & Ryo Higuchi-Sanabria & Liza A. Pon, 2022. "Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Arthur Fischbach & Angela Johns & Kara L. Schneider & Xinxin Hao & Peter Tessarz & Thomas Nyström, 2023. "Artificial Hsp104-mediated systems for re-localizing protein aggregates," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Abdul Haseeb Khan & Xuefang Gu & Rutvik J. Patel & Prabha Chuphal & Matheus P. Viana & Aidan I. Brown & Brian M. Zid & Tatsuhisa Tsuboi, 2024. "Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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