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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

Author

Listed:
  • Jayakrishnan Nandakumar

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    University of Colorado)

  • Caitlin F. Bell

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    University of Colorado
    Present address: Vanderbilt School of Medicine, M.D. program, 215 Light Hall, Nashville, Tennessee 37232, USA.)

  • Ina Weidenfeld

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    Cellular, and Developmental Biology, University of Colorado)

  • Arthur J. Zaug

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    University of Colorado)

  • Leslie A. Leinwand

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    Cellular, and Developmental Biology, University of Colorado)

  • Thomas R. Cech

    (University of Colorado BioFrontiers Institute, Boulder, Colorado 80309, USA
    University of Colorado
    Cellular, and Developmental Biology, University of Colorado)

Abstract

Using separation-of-function mutations of TPP1 that inhibit telomerase binding while maintaining telomere capping, a region on the surface of TPP1, the TEL patch, is identified and found to be required for both binding telomerase and enhancing its processivity.

Suggested Citation

  • Jayakrishnan Nandakumar & Caitlin F. Bell & Ina Weidenfeld & Arthur J. Zaug & Leslie A. Leinwand & Thomas R. Cech, 2012. "The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity," Nature, Nature, vol. 492(7428), pages 285-289, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7428:d:10.1038_nature11648
    DOI: 10.1038/nature11648
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    Cited by:

    1. Angela M. Hinchie & Samantha L. Sanford & Kelly E. Loughridge & Rachel M. Sutton & Anishka H. Parikh & Agustin A. Gil Silva & Daniel I. Sullivan & Pattra Chun-On & Matthew R. Morrell & John F. McDyer , 2024. "A persistent variant telomere sequence in a human pedigree," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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