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Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

Author

Listed:
  • Weiquan Zhu

    (University of Utah
    Program in Molecular Medicine, University of Utah)

  • Nyall R. London

    (University of Utah
    Program in Molecular Medicine, University of Utah
    University of Utah)

  • Christopher C. Gibson

    (Program in Molecular Medicine, University of Utah
    University of Utah)

  • Chadwick T. Davis

    (Program in Molecular Medicine, University of Utah
    University of Utah)

  • Zongzhong Tong

    (Navigen Inc)

  • Lise K. Sorensen

    (Program in Molecular Medicine, University of Utah)

  • Dallas S. Shi

    (Program in Molecular Medicine, University of Utah
    University of Utah)

  • Jinping Guo

    (University of Utah
    Program in Molecular Medicine, University of Utah
    Second Military Medical University)

  • Matthew C. P. Smith

    (University of Utah
    Program in Molecular Medicine, University of Utah
    University of Utah)

  • Allie H. Grossmann

    (Program in Molecular Medicine, University of Utah
    University of Utah)

  • Kirk R. Thomas

    (University of Utah
    Program in Molecular Medicine, University of Utah)

  • Dean Y. Li

    (University of Utah
    Program in Molecular Medicine, University of Utah
    University of Utah
    Cardiology Section, VA Salt Lake City Health Care System)

Abstract

Interleukin-1β-induced disruption to endothelial stability and vascular permeability in a human in vitro model is shown to be independent of downstream nuclear factor-κB activation, relying instead on a MYD88–ARNO–ARF6 signalling cascade; inhibiting proteins involved in this pathway is shown to improve outcomes in animal models of inflammatory disease.

Suggested Citation

  • Weiquan Zhu & Nyall R. London & Christopher C. Gibson & Chadwick T. Davis & Zongzhong Tong & Lise K. Sorensen & Dallas S. Shi & Jinping Guo & Matthew C. P. Smith & Allie H. Grossmann & Kirk R. Thomas , 2012. "Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability," Nature, Nature, vol. 492(7428), pages 252-255, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7428:d:10.1038_nature11603
    DOI: 10.1038/nature11603
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    Cited by:

    1. Yinshen Wee & Junhua Wang & Emily C. Wilson & Coulson P. Rich & Aaron Rogers & Zongzhong Tong & Evelyn DeGroot & Y. N. Vashisht Gopal & Michael A. Davies & H. Atakan Ekiz & Joshua K. H. Tay & Chris St, 2024. "Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Floriane Bretheau & Adrian Castellanos-Molina & Dominic Bélanger & Maxime Kusik & Benoit Mailhot & Ana Boisvert & Nicolas Vallières & Martine Lessard & Matthias Gunzer & Xiaoyu Liu & Éric Boilard & Ni, 2022. "The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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