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Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction

Author

Listed:
  • Marcos Sotomayor

    (Harvard Medical School)

  • Wilhelm A. Weihofen

    (Harvard University
    Present address: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.)

  • Rachelle Gaudet

    (Harvard University)

  • David P. Corey

    (Harvard Medical School)

Abstract

A combination of structural, computational and biophysical tools is used to characterize the bond between tip-link proteins protocadherin 15 and cadherin 23, which have an essential role in inner-ear mechanotransduction; the bond, involving an extended protein handshake, is found to be affected by deafness mutations and is mechanically strong enough to resist forces in hair cells, adding to our understanding of hair-cell sensory transduction and interactions among cadherins.

Suggested Citation

  • Marcos Sotomayor & Wilhelm A. Weihofen & Rachelle Gaudet & David P. Corey, 2012. "Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction," Nature, Nature, vol. 492(7427), pages 128-132, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7427:d:10.1038_nature11590
    DOI: 10.1038/nature11590
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    Cited by:

    1. Maryna V. Ivanchenko & Daniel M. Hathaway & Alex J. Klein & Bifeng Pan & Olga Strelkova & Pedro De-la-Torre & Xudong Wu & Cole W. Peters & Eric M. Mulhall & Kevin T. Booth & Corey Goldstein & Joseph B, 2023. "Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Nisha Arora & Jagadish P. Hazra & Sandip Roy & Gaurav K. Bhati & Sarika Gupta & K. P. Yogendran & Abhishek Chaudhuri & Amin Sagar & Sabyasachi Rakshit, 2024. "Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Elliot Medina & Yathreb Easa & Daniel K. Lester & Eric K. Lau & David Sprinzak & Vincent C. Luca, 2023. "Structure of the planar cell polarity cadherins Fat4 and Dachsous1," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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