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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Author

Listed:
  • Geun-Shik Lee

    (Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health
    College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, South Korea)

  • Naeha Subramanian

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Andrew I. Kim

    (Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health)

  • Ivona Aksentijevich

    (Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health)

  • Raphaela Goldbach-Mansky

    (Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health)

  • David B. Sacks

    (Clinical Center, National Institutes of Health)

  • Ronald N. Germain

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Daniel L. Kastner

    (Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health)

  • Jae Jin Chae

    (Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health)

Abstract

Evidence is presented that activation of the NLRP3 inflammasome is regulated by the calcium-sensing receptor (CASR).

Suggested Citation

  • Geun-Shik Lee & Naeha Subramanian & Andrew I. Kim & Ivona Aksentijevich & Raphaela Goldbach-Mansky & David B. Sacks & Ronald N. Germain & Daniel L. Kastner & Jae Jin Chae, 2012. "The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP," Nature, Nature, vol. 492(7427), pages 123-127, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7427:d:10.1038_nature11588
    DOI: 10.1038/nature11588
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