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Resurrection of endogenous retroviruses in antibody-deficient mice

Author

Listed:
  • George R. Young

    (MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK)

  • Urszula Eksmond

    (MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK)

  • Rosalba Salcedo

    (Basic Science Program, SAIC-Frederick, Inc. and Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute
    National Institutes of Health)

  • Lena Alexopoulou

    (Centre d’Immunologie de Marseille-Luminy (CIML), Aix-Marseille University-UM2, INSERM-U1104, CNRS-UMR7280, Marseille, France)

  • Jonathan P. Stoye

    (MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK)

  • George Kassiotis

    (MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK)

Abstract

Novel pathogenic infectious retroviruses, generated by recombination between replication-defective endogenous retroviruses in the absence of a functional antibody response, are identified; these recombinant retroviruses establish infection of mouse colonies and ultimately cause cancer.

Suggested Citation

  • George R. Young & Urszula Eksmond & Rosalba Salcedo & Lena Alexopoulou & Jonathan P. Stoye & George Kassiotis, 2012. "Resurrection of endogenous retroviruses in antibody-deficient mice," Nature, Nature, vol. 491(7426), pages 774-778, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7426:d:10.1038_nature11599
    DOI: 10.1038/nature11599
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    Cited by:

    1. Eileen Rauch & Timm Amendt & Aleksandra Lopez Krol & Fabian B. Lang & Vincent Linse & Michelle Hohmann & Ann-Christin Keim & Susanne Kreutzer & Kevin Kawengian & Malte Buchholz & Philipp Duschner & Sa, 2024. "T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Shu Liu & Stefanie-Elisabeth Heumüller & André Hossinger & Stephan A. Müller & Oleksandra Buravlova & Stefan F. Lichtenthaler & Philip Denner & Ina M. Vorberg, 2023. "Reactivated endogenous retroviruses promote protein aggregate spreading," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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