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Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Author

Listed:
  • Fabien G. Lafaille

    (Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Itai M. Pessach

    (Children's Hospital, Harvard Medical School
    The Talpiot Medical Leadership Program, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 52621, Israel)

  • Shen-Ying Zhang

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France)

  • Michael J. Ciancanelli

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University)

  • Melina Herman

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France)

  • Avinash Abhyankar

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University)

  • Shui-Wang Ying

    (C.V. Starr Laboratory for Molecular Neuropharmacology, Weill Cornell Medical College)

  • Sotirios Keros

    (Weill Cornell Medical College)

  • Peter A. Goldstein

    (C.V. Starr Laboratory for Molecular Neuropharmacology, Weill Cornell Medical College)

  • Gustavo Mostoslavsky

    (Section of Gastroenterology, Boston University School of Medicine)

  • Jose Ordovas-Montanes

    (Children's Hospital, Harvard Medical School)

  • Emmanuelle Jouanguy

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France)

  • Sabine Plancoulaine

    (Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France)

  • Edmund Tu

    (Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Yechiel Elkabetz

    (Laboratory for Pluripotent and Neural Stem Cell Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel)

  • Saleh Al-Muhsen

    (Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia)

  • Marc Tardieu

    (Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, Kremlin-Bicêtre, 94275, France)

  • Thorsten M. Schlaeger

    (Children's Hospital and Dana-Farber Cancer Institute)

  • George Q. Daley

    (Children's Hospital and Dana-Farber Cancer Institute)

  • Laurent Abel

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France)

  • Jean-Laurent Casanova

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Necker Medical School, U980, Paris 75015, France
    Pediatric Hematology-Immunology Unit, Necker Hospital)

  • Lorenz Studer

    (Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer Research
    Developmental Biology Program, Sloan-Kettering Institute for Cancer Research)

  • Luigi D. Notarangelo

    (Children's Hospital, Harvard Medical School
    The Manton Center for Orphan Disease Research, Children’s Hospital)

Abstract

Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to be more susceptible to infection by HSV-1 than control cells because they fail to induce a normal interferon response, whereas neural stem cells and astrocytes are not susceptible.

Suggested Citation

  • Fabien G. Lafaille & Itai M. Pessach & Shen-Ying Zhang & Michael J. Ciancanelli & Melina Herman & Avinash Abhyankar & Shui-Wang Ying & Sotirios Keros & Peter A. Goldstein & Gustavo Mostoslavsky & Jose, 2012. "Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells," Nature, Nature, vol. 491(7426), pages 769-773, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7426:d:10.1038_nature11583
    DOI: 10.1038/nature11583
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