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Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

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  • Julie B. Sneddon

    (Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA)

  • Malgorzata Borowiak

    (Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA)

  • Douglas A. Melton

    (Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138 USA)

Abstract

The pancreatic lineage is used as a model for embryonic-stem-cell differentiation, and shows that co-culture with organ-matched mesenchyme permits proliferation and self-renewal of progenitors, enabling an expansion of more than a million-fold for human endodermal cells with full retention of developmental potential.

Suggested Citation

  • Julie B. Sneddon & Malgorzata Borowiak & Douglas A. Melton, 2012. "Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme," Nature, Nature, vol. 491(7426), pages 765-768, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7426:d:10.1038_nature11463
    DOI: 10.1038/nature11463
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    Cited by:

    1. Jolanta Chmielowiec & Wojciech J. Szlachcic & Diane Yang & Marissa A. Scavuzzo & Katrina Wamble & Alejandro Sarrion-Perdigones & Omaima M. Sabek & Koen J. T. Venken & Malgorzata Borowiak, 2022. "Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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