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Synaptic amplification by dendritic spines enhances input cooperativity

Author

Listed:
  • Mark T. Harnett

    (HHMI Janelia Farm Research Campus)

  • Judit K. Makara

    (HHMI Janelia Farm Research Campus
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary)

  • Nelson Spruston

    (HHMI Janelia Farm Research Campus)

  • William L. Kath

    (Northwestern University)

  • Jeffrey C. Magee

    (HHMI Janelia Farm Research Campus)

Abstract

Dendritic spines operate as high-impedance input structures that amplify local synaptic depolarization to enhance electrical interaction among coactive inputs.

Suggested Citation

  • Mark T. Harnett & Judit K. Makara & Nelson Spruston & William L. Kath & Jeffrey C. Magee, 2012. "Synaptic amplification by dendritic spines enhances input cooperativity," Nature, Nature, vol. 491(7425), pages 599-602, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11554
    DOI: 10.1038/nature11554
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    Cited by:

    1. Friedrich W Johenning & Anne-Kathrin Theis & Ulrike Pannasch & Martin Rückl & Sten Rüdiger & Dietmar Schmitz, 2015. "Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics," PLOS Biology, Public Library of Science, vol. 13(6), pages 1-29, June.
    2. Annie Lee & Chandana Kondapalli & Daniel M. Virga & Tommy L. Lewis & So Yeon Koo & Archana Ashok & Georges Mairet-Coello & Sebastien Herzig & Marc Foretz & Benoit Viollet & Reuben Shaw & Andrew Sproul, 2022. "Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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