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BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

Author

Listed:
  • Rebecca Mathew

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Michael P. Seiler

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Seth T. Scanlon

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Ai-ping Mao

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Michael G. Constantinides

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Clara Bertozzi-Villa

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

  • Jeffrey D. Singer

    (Portland State University)

  • Albert Bendelac

    (Committee on Immunology, The Howard Hughes Medical Institute, University of Chicago)

Abstract

The E3 ubiquitin ligase cullin 3 is shown to bind BTB-zinc finger transcription factors to direct the ubiquitination of nuclear chromatin-associated factors to control transcription and cell-fate decisions in B- and T-cell populations.

Suggested Citation

  • Rebecca Mathew & Michael P. Seiler & Seth T. Scanlon & Ai-ping Mao & Michael G. Constantinides & Clara Bertozzi-Villa & Jeffrey D. Singer & Albert Bendelac, 2012. "BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs," Nature, Nature, vol. 491(7425), pages 618-621, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11548
    DOI: 10.1038/nature11548
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