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Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

Author

Listed:
  • Beomkyu Kim

    (Stanford University School of Medicine)

  • Alexander Eggel

    (Institute of Immunology, University of Bern, CH-3010 Bern, Switzerland)

  • Svetlana S. Tarchevskaya

    (Stanford University School of Medicine)

  • Monique Vogel

    (Institute of Immunology, University of Bern, CH-3010 Bern, Switzerland)

  • Heino Prinz

    (Max-Planck-Institut fur Molekulare Physiologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany)

  • Theodore S. Jardetzky

    (Stanford University School of Medicine)

Abstract

The interaction between IgE and its receptor FcεRI underlies many allergic responses; here the structure and mechanism of a newly engineered DARPin inhibitor is presented, revealing that it not only blocks the receptor–ligand interaction but also dissociates already-formed complexes.

Suggested Citation

  • Beomkyu Kim & Alexander Eggel & Svetlana S. Tarchevskaya & Monique Vogel & Heino Prinz & Theodore S. Jardetzky, 2012. "Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor," Nature, Nature, vol. 491(7425), pages 613-617, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11546
    DOI: 10.1038/nature11546
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    Cited by:

    1. Luke F. Pennington & Pascal Gasser & Silke Kleinboelting & Chensong Zhang & Georgios Skiniotis & Alexander Eggel & Theodore S. Jardetzky, 2021. "Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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