IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v491y2012i7425d10.1038_nature11536.html
   My bibliography  Save this article

Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts

Author

Listed:
  • Dhvanit I. Shah

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Naoko Takahashi-Makise

    (University of Utah School of Medicine, Salt Lake City, Utah 84312, USA)

  • Jeffrey D. Cooney

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Liangtao Li

    (University of Utah School of Medicine, Salt Lake City, Utah 84312, USA)

  • Iman J. Schultz

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Eric L. Pierce

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Anupama Narla

    (Brigham and Women’s Hospital, Harvard Medical School
    Boston Children’s Hospital, Harvard Medical School)

  • Alexandra Seguin

    (University of Utah School of Medicine, Salt Lake City, Utah 84312, USA)

  • Shilpa M. Hattangadi

    (Boston Children’s Hospital, Harvard Medical School
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Amy E. Medlock

    (Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia)

  • Nathaniel B. Langer

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Tamara A. Dailey

    (Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia)

  • Slater N. Hurst

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Danilo Faccenda

    (Royal Veterinary College, University of London and University College London Consortium for Mitochondrial Research, London NW1 0TU, UK)

  • Jessica M. Wiwczar

    (Dana-Farber Cancer Institute, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Spencer K. Heggers

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Guillaume Vogin

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Wen Chen

    (Brigham and Women’s Hospital, Harvard Medical School
    Present addresses: University of Texas Health Science Center, San Antonio, Texas 78229, USA (J.D.C.); InteRNA Technologies, 3584 CH Utrecht, The Netherlands (I.J.S.); Georgia Institute of Technology, Atlanta, Georgia 30332, USA (E.L.P.); Yale University, New Haven, Connecticut 06510, USA (S.M.H. and J.M.W.); Columbia University, New York, New York 10032, USA (N.B.L.); Alexis Vautrin Cancer Centre, 54511 Vandoeuvre-Les-Nancy Cedex, France (G.V.); and Texas A&M Health Science Center, Temple, Texas 76504, USA (W.C.).)

  • Caiyong Chen

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Dean R. Campagna

    (Boston Children’s Hospital, Harvard Medical School)

  • Carlo Brugnara

    (Boston Children’s Hospital, Harvard Medical School)

  • Yi Zhou

    (Boston Children’s Hospital, Harvard Medical School)

  • Benjamin L. Ebert

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Nika N. Danial

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Mark D. Fleming

    (Boston Children’s Hospital, Harvard Medical School)

  • Diane M. Ward

    (University of Utah School of Medicine, Salt Lake City, Utah 84312, USA)

  • Michelangelo Campanella

    (Royal Veterinary College, University of London and University College London Consortium for Mitochondrial Research, London NW1 0TU, UK)

  • Harry A. Dailey

    (Biomedical and Health Sciences Institute, Biochemistry & Molecular Biology, University of Georgia)

  • Jerry Kaplan

    (University of Utah School of Medicine, Salt Lake City, Utah 84312, USA)

  • Barry H. Paw

    (Brigham and Women’s Hospital, Harvard Medical School
    Boston Children’s Hospital, Harvard Medical School)

Abstract

Atpif1, a mitochondrial ATPase inhibitor, was identified as a zebrafish anemic mutant, pinotage, providing an important link in our understanding of the relationship between mitochondrial homeostasis and haem synthesis and identifying a gene that may have a role in human iron, haem and mitochondrial diseases.

Suggested Citation

  • Dhvanit I. Shah & Naoko Takahashi-Makise & Jeffrey D. Cooney & Liangtao Li & Iman J. Schultz & Eric L. Pierce & Anupama Narla & Alexandra Seguin & Shilpa M. Hattangadi & Amy E. Medlock & Nathaniel B. , 2012. "Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts," Nature, Nature, vol. 491(7425), pages 608-612, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11536
    DOI: 10.1038/nature11536
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11536
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11536?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11536. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.