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Metabolic phenotyping in clinical and surgical environments

Author

Listed:
  • Jeremy K. Nicholson

    (Faculty of Medicine, Imperial College London)

  • Elaine Holmes

    (Faculty of Medicine, Imperial College London)

  • James M. Kinross

    (Faculty of Medicine, Imperial College London)

  • Ara W. Darzi

    (Faculty of Medicine, Imperial College London)

  • Zoltan Takats

    (Faculty of Medicine, Imperial College London)

  • John C. Lindon

    (Faculty of Medicine, Imperial College London)

Abstract

Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's physiological or pathological states that relate to disease diagnosis or prognosis at the individual level and to disease risk factors at the population level. These approaches are currently being implemented in hospital environments and in regional phenotyping centres worldwide. The ultimate aim of such work is to generate information on patient biology using techniques such as patient stratification to better inform clinicians on factors that will enhance diagnosis or the choice of therapy. There have been many reports of direct applications of metabolic phenotyping in a clinical setting.

Suggested Citation

  • Jeremy K. Nicholson & Elaine Holmes & James M. Kinross & Ara W. Darzi & Zoltan Takats & John C. Lindon, 2012. "Metabolic phenotyping in clinical and surgical environments," Nature, Nature, vol. 491(7424), pages 384-392, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7424:d:10.1038_nature11708
    DOI: 10.1038/nature11708
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    Cited by:

    1. Minvielle, Etienne & Waelli, Mathias & Sicotte, Claude & Kimberly, John R., 2014. "Managing customization in health care: A framework derived from the services sector literature," Health Policy, Elsevier, vol. 117(2), pages 216-227.

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