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An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

Author

Listed:
  • Devarati Mitra

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Xi Luo

    (Massachusetts General Hospital Cancer Center)

  • Ann Morgan

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Jin Wang

    (University of California)

  • Mai P. Hoang

    (Massachusetts General Hospital)

  • Jennifer Lo

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Candace R. Guerrero

    (University of California)

  • Jochen K. Lennerz

    (Institute of Pathology, University Ulm, Ulm 89070, Germany)

  • Martin C. Mihm

    (Massachusetts General Hospital)

  • Jennifer A. Wargo

    (Massachusetts General Hospital)

  • Kathleen C. Robinson

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Suprabha P. Devi

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

  • Jillian C. Vanover

    (Markey Cancer Center, University of Kentucky School of Medicine)

  • John A. D’Orazio

    (Markey Cancer Center, University of Kentucky School of Medicine)

  • Martin McMahon

    (Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Marcus W. Bosenberg

    (Yale University School of Medicine)

  • Kevin M. Haigis

    (Massachusetts General Hospital Cancer Center)

  • Daniel A. Haber

    (Massachusetts General Hospital Cancer Center)

  • Yinsheng Wang

    (University of California)

  • David E. Fisher

    (Cutaneous Biology Research Center, Massachusetts General Hospital)

Abstract

Individuals with the red hair/fair skin phenotype usually carry a polymorphism in the gene encoding the melanocortin 1 receptor (Mc1r) that results in the production of pigment containing a high pheomelanin-to-eumelanin ratio; here it is shown in a mouse model that inactivation of Mc1r promotes melanoma formation in the presence of the Braf oncogene, thus suggesting that pheomelanin synthesis is carcinogenic by an ultraviolet-radiation-independent mechanism.

Suggested Citation

  • Devarati Mitra & Xi Luo & Ann Morgan & Jin Wang & Mai P. Hoang & Jennifer Lo & Candace R. Guerrero & Jochen K. Lennerz & Martin C. Mihm & Jennifer A. Wargo & Kathleen C. Robinson & Suprabha P. Devi & , 2012. "An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background," Nature, Nature, vol. 491(7424), pages 449-453, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7424:d:10.1038_nature11624
    DOI: 10.1038/nature11624
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    Cited by:

    1. Yasunori Sato & Eriko Uchida & Hitoshi Aoki & Takayuki Hanamura & Kenichi Nagamine & Hisanori Kato & Takeshi Koizumi & Akihito Ishigami, 2017. "Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.

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