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A bimodular mechanism of calcium control in eukaryotes

Author

Listed:
  • Henning Tidow

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark)

  • Lisbeth R. Poulsen

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark)

  • Antonina Andreeva

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Michael Knudsen

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    Bioinformatics Research Centre, Aarhus University, CF Møllers Allé 8, DK-8000 Aarhus C, Denmark)

  • Kim L. Hein

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    Present address: Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, PO Box 1125, Blindern, N-0318 Oslo, Norway.)

  • Carsten Wiuf

    (University of Copenhagen, Universitetsparken 5)

  • Michael G. Palmgren

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark)

  • Poul Nissen

    (Centre for Membrane Pumps in Cells and Disease — PUMPKIN, Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark
    Aarhus University, Gustav Wieds Vej 10c, DK-8000 Aarhus C, Denmark)

Abstract

Detailed characterization of the regulatory domain of a plasma-membrane Ca2+-ATPase — a calcium pump — in complex with calmodulin results in a two-step structural model that explains how calmodulin-mediated regulation of pump activation affords highly responsive control over the intracellular calcium concentration in eukaryotes.

Suggested Citation

  • Henning Tidow & Lisbeth R. Poulsen & Antonina Andreeva & Michael Knudsen & Kim L. Hein & Carsten Wiuf & Michael G. Palmgren & Poul Nissen, 2012. "A bimodular mechanism of calcium control in eukaryotes," Nature, Nature, vol. 491(7424), pages 468-472, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7424:d:10.1038_nature11539
    DOI: 10.1038/nature11539
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    Cited by:

    1. Annie M Westerlund & Lucie Delemotte, 2018. "Effect of Ca2+ on the promiscuous target-protein binding of calmodulin," PLOS Computational Biology, Public Library of Science, vol. 14(4), pages 1-27, April.

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