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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

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Listed:
  • Samuel Huber

    (Yale University School of Medicine
    I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany)

  • Nicola Gagliani

    (Yale University School of Medicine)

  • Lauren A. Zenewicz

    (Yale University School of Medicine)

  • Francis J. Huber

    (I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany)

  • Lidia Bosurgi

    (Yale University School of Medicine)

  • Bo Hu

    (Yale University School of Medicine)

  • Matija Hedl

    (Section of Digestive Diseases, Yale University)

  • Wei Zhang

    (Section of Digestive Diseases, Yale University School of Medicine)

  • William O’Connor

    (Yale University School of Medicine)

  • Andrew J. Murphy

    (Regeneron Pharmaceuticals, Inc.)

  • David M. Valenzuela

    (Regeneron Pharmaceuticals, Inc.)

  • George D. Yancopoulos

    (Regeneron Pharmaceuticals, Inc.)

  • Carmen J. Booth

    (Section of Comparative Medicine, Yale University School of Medicine)

  • Judy H. Cho

    (Section of Digestive Diseases, Yale University School of Medicine)

  • Wenjun Ouyang

    (Genentech, Inc., South San Francisco, California 94080, USA)

  • Clara Abraham

    (Section of Digestive Diseases, Yale University)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

Abstract

IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unanticipated mechanism, controlling IL-22 and thereby the development of colon cancer.

Suggested Citation

  • Samuel Huber & Nicola Gagliani & Lauren A. Zenewicz & Francis J. Huber & Lidia Bosurgi & Bo Hu & Matija Hedl & Wei Zhang & William O’Connor & Andrew J. Murphy & David M. Valenzuela & George D. Yancopo, 2012. "IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine," Nature, Nature, vol. 491(7423), pages 259-263, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11535
    DOI: 10.1038/nature11535
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