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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

Author

Listed:
  • Ayumi Yoshizaki

    (Duke University Medical Center)

  • Tomomitsu Miyagaki

    (Duke University Medical Center)

  • David J. DiLillo

    (Duke University Medical Center)

  • Takashi Matsushita

    (Duke University Medical Center)

  • Mayuka Horikawa

    (Duke University Medical Center)

  • Evgueni I. Kountikov

    (Duke University Medical Center)

  • Rosanne Spolski

    (Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Jonathan C. Poe

    (Duke University Medical Center)

  • Warren J. Leonard

    (Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Thomas F. Tedder

    (Duke University Medical Center)

Abstract

IL-21- and CD40-dependent cognate interactions with T cells are identified as key drivers for the generation of IL-10-producing regulatory B cells, which can protect against autoimmune disease.

Suggested Citation

  • Ayumi Yoshizaki & Tomomitsu Miyagaki & David J. DiLillo & Takashi Matsushita & Mayuka Horikawa & Evgueni I. Kountikov & Rosanne Spolski & Jonathan C. Poe & Warren J. Leonard & Thomas F. Tedder, 2012. "Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions," Nature, Nature, vol. 491(7423), pages 264-268, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11501
    DOI: 10.1038/nature11501
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