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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Author

Listed:
  • Sergei I. Grivennikov

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Kepeng Wang

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, No. 1120, Lianhua Road, Shenzhen, Guangdong Province, China)

  • Daniel Mucida

    (La Jolla Institute for Allergy and Immunology
    Laboratory of Mucosal Immunology, The Rockefeller University)

  • C. Andrew Stewart

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Bernd Schnabl

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Dominik Jauch

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Koji Taniguchi

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    Keio University School of Medicine, Tokyo 160-8582, Japan)

  • Guann-Yi Yu

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Christoph H. Österreicher

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    Institute of Pharmacology, Center for Physiology and Pharmacology Medical University of Vienna)

  • Kenneth E. Hung

    (Tufts Medical Center)

  • Christian Datz

    (Oberndorf Hospital, Paracelsus Medical University)

  • Ying Feng

    (Human Genetics and Pathology, University of Michigan Medical School)

  • Eric R. Fearon

    (Human Genetics and Pathology, University of Michigan Medical School)

  • Mohamed Oukka

    (Seattle Children’s Research Institute)

  • Lino Tessarollo

    (Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health)

  • Vincenzo Coppola

    (Immunology & Medical Genetics, Ohio State University Comprehensive Cancer Center, Wexner Medical Center)

  • Felix Yarovinsky

    (University of Texas Southwestern Medical Center at Dallas)

  • Hilde Cheroutre

    (La Jolla Institute for Allergy and Immunology)

  • Lars Eckmann

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Giorgio Trinchieri

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

Abstract

In a mouse model of colorectal cancer, barrier deterioration results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives IL-23-dependent tumour growth.

Suggested Citation

  • Sergei I. Grivennikov & Kepeng Wang & Daniel Mucida & C. Andrew Stewart & Bernd Schnabl & Dominik Jauch & Koji Taniguchi & Guann-Yi Yu & Christoph H. Österreicher & Kenneth E. Hung & Christian Datz & , 2012. "Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth," Nature, Nature, vol. 491(7423), pages 254-258, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11465
    DOI: 10.1038/nature11465
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    Cited by:

    1. En-Bo Wu & Fung-Chang Sung & Cheng-Li Lin & Kuen-Lin Wu & Kuen-Bao Chen, 2021. "Colorectal Cancer Risk in Patients with Hemorrhoids: A 10-Year Population-Based Retrospective Cohort Study," IJERPH, MDPI, vol. 18(16), pages 1-10, August.

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