IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v491y2012i7423d10.1038_nature11444.html
   My bibliography  Save this article

CaMKII determines mitochondrial stress responses in heart

Author

Listed:
  • Mei-ling A. Joiner

    (Carver College of Medicine, University of Iowa)

  • Olha M. Koval

    (Carver College of Medicine, University of Iowa)

  • Jingdong Li

    (Carver College of Medicine, University of Iowa
    Present address: The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA.)

  • B. Julie He

    (Carver College of Medicine, University of Iowa
    Carver College of Medicine, University of Iowa)

  • Chantal Allamargot

    (University of Iowa Central Microscopy Research Facility, Carver College of Medicine, University of Iowa)

  • Zhan Gao

    (Carver College of Medicine, University of Iowa)

  • Elizabeth D. Luczak

    (Carver College of Medicine, University of Iowa)

  • Duane D. Hall

    (Carver College of Medicine, University of Iowa)

  • Brian D. Fink

    (Iowa City Veterans Affairs Medical Center)

  • Biyi Chen

    (Carver College of Medicine, University of Iowa)

  • Jinying Yang

    (Carver College of Medicine, University of Iowa)

  • Steven A. Moore

    (Carver College of Medicine, University of Iowa
    Carver College of Medicine, University of Iowa)

  • Thomas D. Scholz

    (Carver College of Medicine, University of Iowa)

  • Stefan Strack

    (Carver College of Medicine, University of Iowa)

  • Peter J. Mohler

    (Carver College of Medicine, University of Iowa
    Present address: The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA.)

  • William I. Sivitz

    (Carver College of Medicine, University of Iowa
    Iowa City Veterans Affairs Medical Center)

  • Long-Sheng Song

    (Carver College of Medicine, University of Iowa)

  • Mark E. Anderson

    (Carver College of Medicine, University of Iowa
    Carver College of Medicine, University of Iowa)

Abstract

Calcium exchange and cardiac stress Increased mitochondrial calcium entry has been implicated in myocardial death, heart failure and related conditions. Here, the authors show that inhibition of the multifunctional Ca2+- and calmodulin-dependent protein kinase II (CaMKII) in a mouse model of ischaemia reperfusion injury reduces infarct size and mitochondrial-triggered cell death and dysfunction. This is due to reduced mitochondrial Ca2+ entry through the mitochondrial calcium uniporter and enhanced Ca2+ tolerance of the mitochondrial permeability transition pore. This suggests that CaMKII inhibition could reduce adverse responses to common forms of pathological myocardial stress.

Suggested Citation

  • Mei-ling A. Joiner & Olha M. Koval & Jingdong Li & B. Julie He & Chantal Allamargot & Zhan Gao & Elizabeth D. Luczak & Duane D. Hall & Brian D. Fink & Biyi Chen & Jinying Yang & Steven A. Moore & Thom, 2012. "CaMKII determines mitochondrial stress responses in heart," Nature, Nature, vol. 491(7423), pages 269-273, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11444
    DOI: 10.1038/nature11444
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11444
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11444?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11444. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.