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The molecular basis of phosphate discrimination in arsenate-rich environments

Author

Listed:
  • Mikael Elias

    (Weizmann Institute of Science)

  • Alon Wellner

    (Weizmann Institute of Science)

  • Korina Goldin-Azulay

    (Weizmann Institute of Science)

  • Eric Chabriere

    (Unité de recherche sur les maladies infectieuses et tropicales émergentes, Faculté de Médecine et de Pharmacie, CNRS-Université de la Méditerranée, 13385 Marseille, France)

  • Julia A. Vorholt

    (Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland)

  • Tobias J. Erb

    (Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland)

  • Dan S. Tawfik

    (Weizmann Institute of Science)

Abstract

Ultrahigh-resolution X-ray crystallography study of a phosphate-binding protein from Pseudomonas fluorescens yields insight into how phosphate ions essential for life are discriminated from the arsenate ions inimical to it, even in arsenate-rich environments.

Suggested Citation

  • Mikael Elias & Alon Wellner & Korina Goldin-Azulay & Eric Chabriere & Julia A. Vorholt & Tobias J. Erb & Dan S. Tawfik, 2012. "The molecular basis of phosphate discrimination in arsenate-rich environments," Nature, Nature, vol. 491(7422), pages 134-137, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11517
    DOI: 10.1038/nature11517
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