IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v491y2012i7422d10.1038_nature11433.html
   My bibliography  Save this article

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

Author

Listed:
  • Manqing Li

    (Section of Molecular Biology, University of California San Diego)

  • Elaine Kao

    (Section of Molecular Biology, University of California San Diego)

  • Xia Gao

    (Section of Molecular Biology, University of California San Diego)

  • Hilary Sandig

    (Section of Molecular Biology, University of California San Diego)

  • Kirsten Limmer

    (Section of Molecular Biology, University of California San Diego)

  • Mariana Pavon-Eternod

    (University of Chicago)

  • Thomas E. Jones

    (University of Chicago)

  • Sebastien Landry

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Tao Pan

    (University of Chicago)

  • Matthew D. Weitzman

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Michael David

    (Section of Molecular Biology, University of California San Diego
    Moores Cancer Center, University of California San Diego)

Abstract

Schlafen proteins are produced in response to interferon signalling, which can be activated by retroviral infection; this study shows that human schlafen 11 inhibits the late stages of HIV-1 production by binding non-specifically to tRNAs, thus preventing the expression of viral proteins.

Suggested Citation

  • Manqing Li & Elaine Kao & Xia Gao & Hilary Sandig & Kirsten Limmer & Mariana Pavon-Eternod & Thomas E. Jones & Sebastien Landry & Tao Pan & Matthew D. Weitzman & Michael David, 2012. "Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11," Nature, Nature, vol. 491(7422), pages 125-128, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11433
    DOI: 10.1038/nature11433
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11433
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11433?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jie Chen & Nan Liu & Yinpin Huang & Yuanxun Wang & Yuxing Sun & Qingcui Wu & Dianrong Li & Shuanhu Gao & Hong-Wei Wang & Niu Huang & Xiangbing Qi & Xiaodong Wang, 2021. "Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Felix J. Metzner & Simon J. Wenzl & Michael Kugler & Stefan Krebs & Karl-Peter Hopfner & Katja Lammens, 2022. "Mechanistic understanding of human SLFN11," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11433. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.