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Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

Author

Listed:
  • Manqing Li

    (Section of Molecular Biology, University of California San Diego)

  • Elaine Kao

    (Section of Molecular Biology, University of California San Diego)

  • Xia Gao

    (Section of Molecular Biology, University of California San Diego)

  • Hilary Sandig

    (Section of Molecular Biology, University of California San Diego)

  • Kirsten Limmer

    (Section of Molecular Biology, University of California San Diego)

  • Mariana Pavon-Eternod

    (University of Chicago)

  • Thomas E. Jones

    (University of Chicago)

  • Sebastien Landry

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Tao Pan

    (University of Chicago)

  • Matthew D. Weitzman

    (Laboratory of Genetics, The Salk Institute for Biological Studies)

  • Michael David

    (Section of Molecular Biology, University of California San Diego
    Moores Cancer Center, University of California San Diego)

Abstract

Schlafen proteins are produced in response to interferon signalling, which can be activated by retroviral infection; this study shows that human schlafen 11 inhibits the late stages of HIV-1 production by binding non-specifically to tRNAs, thus preventing the expression of viral proteins.

Suggested Citation

  • Manqing Li & Elaine Kao & Xia Gao & Hilary Sandig & Kirsten Limmer & Mariana Pavon-Eternod & Thomas E. Jones & Sebastien Landry & Tao Pan & Matthew D. Weitzman & Michael David, 2012. "Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11," Nature, Nature, vol. 491(7422), pages 125-128, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11433
    DOI: 10.1038/nature11433
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    Cited by:

    1. Felix J. Metzner & Simon J. Wenzl & Michael Kugler & Stefan Krebs & Karl-Peter Hopfner & Katja Lammens, 2022. "Mechanistic understanding of human SLFN11," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Jie Chen & Nan Liu & Yinpin Huang & Yuanxun Wang & Yuxing Sun & Qingcui Wu & Dianrong Li & Shuanhu Gao & Hong-Wei Wang & Niu Huang & Xiangbing Qi & Xiaodong Wang, 2021. "Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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