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Clonal allelic predetermination of immunoglobulin-κ rearrangement

Author

Listed:
  • Marganit Farago

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Chaggai Rosenbluh

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Maya Tevlin

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel
    Present address: Laboratory of Developmental Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.)

  • Shira Fraenkel

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Sharon Schlesinger

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Hagit Masika

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Masha Gouzman

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Grace Teng

    (Yale University School of Medicine, 300 Cedar Street, PO Box 208011, New Haven, Connecticut 06520, USA)

  • David Schatz

    (Yale University School of Medicine, 300 Cedar Street, PO Box 208011, New Haven, Connecticut 06520, USA
    Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA)

  • Yoach Rais

    (Weizmann Institute of Science)

  • Jacob H. Hanna

    (Weizmann Institute of Science)

  • Alexander Mildner

    (Weizmann Institute of Science)

  • Steffen Jung

    (Weizmann Institute of Science)

  • Gustavo Mostoslavsky

    (Center for Regenerative Medicine (CReM), Boston University School of Medicine, 650 Albany Street, Suite 513, Boston, Massachusetts 02118, USA)

  • Howard Cedar

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

  • Yehudit Bergman

    (Institute for Medical Research Israel–Canada, Hebrew University Medical School, POB 12272, Ein Kerem, Jerusalem 91120, Israel)

Abstract

Immunoglobulin genes are expressed from either the maternal or paternal chromosome; it is now shown that in early haematopoietic stem cells, an individual cell can choose either of the two alleles, but as they develop they become committed to only one.

Suggested Citation

  • Marganit Farago & Chaggai Rosenbluh & Maya Tevlin & Shira Fraenkel & Sharon Schlesinger & Hagit Masika & Masha Gouzman & Grace Teng & David Schatz & Yoach Rais & Jacob H. Hanna & Alexander Mildner & S, 2012. "Clonal allelic predetermination of immunoglobulin-κ rearrangement," Nature, Nature, vol. 490(7421), pages 561-565, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7421:d:10.1038_nature11496
    DOI: 10.1038/nature11496
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