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Black mamba venom peptides target acid-sensing ion channels to abolish pain

Author

Listed:
  • Sylvie Diochot

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France)

  • Anne Baron

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France)

  • Miguel Salinas

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France)

  • Dominique Douguet

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France)

  • Sabine Scarzello

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    Present address: IRCAN, CNRS UMR 7284, Inserm U1081, UNS, 06107 Nice, France.)

  • Anne-Sophie Dabert-Gay

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France)

  • Delphine Debayle

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France)

  • Valérie Friend

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France)

  • Abdelkrim Alloui

    (Clermont Université, Université d’Auvergne, NEURO-DOL, BP 10448, F-63000 Clermont-Ferrand, France
    Inserm U1107, F-63001 Clermont-Ferrand, France)

  • Michel Lazdunski

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France)

  • Eric Lingueglia

    (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Université de Nice-Sophia Antipolis, 06560 Valbonne, France
    LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France)

Abstract

A new class of peptides, mambalgins, is isolated from the African snake the black mamba, which can abolish pain through inhibition of particular subtypes of acid-sensing ion channels expressed either in central or peripheral neurons.

Suggested Citation

  • Sylvie Diochot & Anne Baron & Miguel Salinas & Dominique Douguet & Sabine Scarzello & Anne-Sophie Dabert-Gay & Delphine Debayle & Valérie Friend & Abdelkrim Alloui & Michel Lazdunski & Eric Lingueglia, 2012. "Black mamba venom peptides target acid-sensing ion channels to abolish pain," Nature, Nature, vol. 490(7421), pages 552-555, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7421:d:10.1038_nature11494
    DOI: 10.1038/nature11494
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    Cited by:

    1. Pietro Mesirca & Jean Chemin & Christian Barrère & Eleonora Torre & Laura Gallot & Arnaud Monteil & Isabelle Bidaud & Sylvie Diochot & Michel Lazdunski & Tuck Wah Soong & Stéphanie Barrère-Lemaire & M, 2024. "Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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