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Phosphorylation of NLRC4 is critical for inflammasome activation

Author

Listed:
  • Yan Qu

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Shahram Misaghi

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Anita Izrael-Tomasevic

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Kim Newton

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Laurie L. Gilmour

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Mohamed Lamkanfi

    (VIB, B-9000 Ghent, Belgium
    Ghent University, B-9000 Ghent, Belgium)

  • Salina Louie

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Nobuhiko Kayagaki

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jinfeng Liu

    (1 DNA Way)

  • László Kömüves

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • James E. Cupp

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David Arnott

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Denise Monack

    (Stanford School of Medicine)

  • Vishva M. Dixit

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Phosphorylation of the NOD-like receptor NLRC4 is essential for activation of the NLRC4 inflammasome complex in response to bacterial stimuli.

Suggested Citation

  • Yan Qu & Shahram Misaghi & Anita Izrael-Tomasevic & Kim Newton & Laurie L. Gilmour & Mohamed Lamkanfi & Salina Louie & Nobuhiko Kayagaki & Jinfeng Liu & László Kömüves & James E. Cupp & David Arnott &, 2012. "Phosphorylation of NLRC4 is critical for inflammasome activation," Nature, Nature, vol. 490(7421), pages 539-542, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7421:d:10.1038_nature11429
    DOI: 10.1038/nature11429
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    Cited by:

    1. Mohamed F. Mohamed & Kajal Gupta & Josef W. Goldufsky & Ruchi Roy & Lauren T. Callaghan & Dawn M. Wetzel & Timothy M. Kuzel & Jochen Reiser & Sasha H. Shafikhani, 2022. "CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. David Martino & Nina Kresoje & Nelly Amenyogbe & Rym Ben-Othman & Bing Cai & Mandy Lo & Olubukola Idoko & Oludare A. Odumade & Reza Falsafi & Travis M. Blimkie & Andy An & Casey P. Shannon & Sebastian, 2024. "DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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