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Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

Author

Listed:
  • Jennifer Landsberg

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Judith Kohlmeyer

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Marcel Renn

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Tobias Bald

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Meri Rogava

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Mira Cron

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

  • Martina Fatho

    (Haematology/Oncology/Pneumology, University Medical Centre of the Johannes Gutenberg University, D-55101 Mainz, Germany)

  • Volker Lennerz

    (Haematology/Oncology/Pneumology, University Medical Centre of the Johannes Gutenberg University, D-55101 Mainz, Germany)

  • Thomas Wölfel

    (Haematology/Oncology/Pneumology, University Medical Centre of the Johannes Gutenberg University, D-55101 Mainz, Germany)

  • Michael Hölzel

    (Unit for RNA Biology, University of Bonn, D-53105 Bonn, Germany)

  • Thomas Tüting

    (Laboratory of Experimental Dermatology, University of Bonn, D-53105 Bonn, Germany)

Abstract

A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.

Suggested Citation

  • Jennifer Landsberg & Judith Kohlmeyer & Marcel Renn & Tobias Bald & Meri Rogava & Mira Cron & Martina Fatho & Volker Lennerz & Thomas Wölfel & Michael Hölzel & Thomas Tüting, 2012. "Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation," Nature, Nature, vol. 490(7420), pages 412-416, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11538
    DOI: 10.1038/nature11538
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    Cited by:

    1. Yan, Kexun & Wang, Maoxiang & Hu, Fenglan & Xu, Meng, 2023. "Effect of cellular dedifferentiation on the growth of cell lineages," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 632(P1).

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