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Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

Author

Listed:
  • Carolina E. Hagberg

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet)

  • Annika Mehlem

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden)

  • Annelie Falkevall

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet)

  • Lars Muhl

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Ludwig Institute for Cancer Research Ltd, Stockholm Branch, Karolinska Institutet)

  • Barbara C. Fam

    (University of Melbourne)

  • Henrik Ortsäter

    (Diabetes Research Unit, Södersjukhuset, Karolinska Institutet)

  • Pierre Scotney

    (CSL Limited)

  • Daniel Nyqvist

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden)

  • Erik Samén

    (Karolinska University Hospital
    Clinical Neurosciences, Karolinska Institutet)

  • Li Lu

    (Karolinska University Hospital)

  • Sharon Stone-Elander

    (Karolinska University Hospital
    Clinical Neurosciences, Karolinska Institutet)

  • Joseph Proietto

    (University of Melbourne)

  • Sofianos Andrikopoulos

    (University of Melbourne)

  • Åke Sjöholm

    (Diabetes Research Unit, Södersjukhuset, Karolinska Institutet)

  • Andrew Nash

    (CSL Limited)

  • Ulf Eriksson

    (Tissue Biology Group, Karolinska Institutet, SE-171 77 Stockholm, Sweden)

Abstract

Inhibition of VEGF-B signalling is shown to limit ectopic fatty-acid accumulation, restore peripheral insulin sensitivity and muscle glucose uptake, and preserve pancreatic islet functionality.

Suggested Citation

  • Carolina E. Hagberg & Annika Mehlem & Annelie Falkevall & Lars Muhl & Barbara C. Fam & Henrik Ortsäter & Pierre Scotney & Daniel Nyqvist & Erik Samén & Li Lu & Sharon Stone-Elander & Joseph Proietto &, 2012. "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes," Nature, Nature, vol. 490(7420), pages 426-430, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11464
    DOI: 10.1038/nature11464
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