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Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive

Author

Listed:
  • Julia C. Lemos

    (University of Washington
    University of Washington
    Program in Neurobiology and Behavior, University of Washington)

  • Matthew J. Wanat

    (University of Washington
    University of Washington)

  • Jeffrey S. Smith

    (University of Washington)

  • Beverly A. S. Reyes

    (Farber Institute for Neurosciences, Thomas Jefferson University)

  • Nick G. Hollon

    (University of Washington
    University of Washington
    Program in Neurobiology and Behavior, University of Washington)

  • Elisabeth J. Van Bockstaele

    (Farber Institute for Neurosciences, Thomas Jefferson University)

  • Charles Chavkin

    (University of Washington
    Program in Neurobiology and Behavior, University of Washington)

  • Paul E. M. Phillips

    (University of Washington
    University of Washington
    Program in Neurobiology and Behavior, University of Washington)

Abstract

The neuropeptide corticotropin-releasing factor (CRF) acts in the nucleus accumbens of mice to increase dopamine release through coactivation of CRF receptor 1 (CRFR1) and CRFR2, but exposure to severe stress results in loss of this regulation and a switch in the reaction to CRF from appetitive to aversive.

Suggested Citation

  • Julia C. Lemos & Matthew J. Wanat & Jeffrey S. Smith & Beverly A. S. Reyes & Nick G. Hollon & Elisabeth J. Van Bockstaele & Charles Chavkin & Paul E. M. Phillips, 2012. "Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive," Nature, Nature, vol. 490(7420), pages 402-406, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11436
    DOI: 10.1038/nature11436
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    Cited by:

    1. Matthew T. Birnie & Annabel K. Short & Gregory B. Carvalho & Lara Taniguchi & Benjamin G. Gunn & Aidan L. Pham & Christy A. Itoga & Xiangmin Xu & Lulu Y. Chen & Stephen V. Mahler & Yuncai Chen & Talli, 2023. "Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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