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Initiation of transcription-coupled repair characterized at single-molecule resolution

Author

Listed:
  • Kévin Howan

    (Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
    Present addresses: Statistical Physics Laboratory, Ecole Normale Superieure, 24 rue Lhomond 75005 Paris (K.H.); Department of Pathology and Laboratory Medicine, Division of Infectious Disease Diagnostics, North Shore LIJ Health System Laboratories, 10 Nevada Drive, Lake Success, New York 11718, USA (L.F.W.); Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA (S.Z.).)

  • Abigail J. Smith

    (DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK)

  • Lars F. Westblade

    (The Rockefeller University, 1230 York Avenue
    Present addresses: Statistical Physics Laboratory, Ecole Normale Superieure, 24 rue Lhomond 75005 Paris (K.H.); Department of Pathology and Laboratory Medicine, Division of Infectious Disease Diagnostics, North Shore LIJ Health System Laboratories, 10 Nevada Drive, Lake Success, New York 11718, USA (L.F.W.); Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA (S.Z.).)

  • Nicolas Joly

    (Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France)

  • Wilfried Grange

    (Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France)

  • Sylvain Zorman

    (Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France
    Present addresses: Statistical Physics Laboratory, Ecole Normale Superieure, 24 rue Lhomond 75005 Paris (K.H.); Department of Pathology and Laboratory Medicine, Division of Infectious Disease Diagnostics, North Shore LIJ Health System Laboratories, 10 Nevada Drive, Lake Success, New York 11718, USA (L.F.W.); Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA (S.Z.).)

  • Seth A. Darst

    (The Rockefeller University, 1230 York Avenue)

  • Nigel J. Savery

    (DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK)

  • Terence R. Strick

    (Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité F-75205 Paris, France)

Abstract

The early stages of transcription-coupled DNA repair are observed at single-molecule resolution; the Escherichia coli DNA translocase molecule Mfd is shown to promote RNA polymerase dissociation by catalysing two irreversible, ATP-dependent transitions.

Suggested Citation

  • Kévin Howan & Abigail J. Smith & Lars F. Westblade & Nicolas Joly & Wilfried Grange & Sylvain Zorman & Seth A. Darst & Nigel J. Savery & Terence R. Strick, 2012. "Initiation of transcription-coupled repair characterized at single-molecule resolution," Nature, Nature, vol. 490(7420), pages 431-434, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11430
    DOI: 10.1038/nature11430
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