IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v490y2012i7419d10.1038_nature11466.html
   My bibliography  Save this article

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

Author

Listed:
  • Nicolas X. Tritsch

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Jun B. Ding

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Present address: Department of Neurology and Neurological Sciences, Stanford Institute of Neuro-innovation and Translational Neurosciences (SINTN), Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, California 94304, USA.)

  • Bernardo L. Sabatini

    (Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

Activation of midbrain dopamine neurons rapidly inhibits action potential firing in both direct- and indirect-pathway striatal projection neurons through VMAT2-dependent vesicular release of the inhibitory transmitter GABA (γ-aminobutyric acid).

Suggested Citation

  • Nicolas X. Tritsch & Jun B. Ding & Bernardo L. Sabatini, 2012. "Dopaminergic neurons inhibit striatal output through non-canonical release of GABA," Nature, Nature, vol. 490(7419), pages 262-266, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7419:d:10.1038_nature11466
    DOI: 10.1038/nature11466
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11466
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11466?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Vincent Paget-Blanc & Marlene E. Pfeffer & Marie Pronot & Paul Lapios & Maria-Florencia Angelo & Roman Walle & Fabrice P. Cordelières & Florian Levet & Stéphane Claverol & Sabrina Lacomme & Mélina Pet, 2022. "A synaptomic analysis reveals dopamine hub synapses in the mouse striatum," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Davide Cenci & Manuel Glauco Carbone & Camilla Callegari & Icro Maremmani, 2022. "Psychomotor Symptoms in Chronic Cocaine Users: An Interpretative Model," IJERPH, MDPI, vol. 19(3), pages 1-10, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:490:y:2012:i:7419:d:10.1038_nature11466. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.