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HIV-infected T cells are migratory vehicles for viral dissemination

Author

Listed:
  • Thomas T. Murooka

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Maud Deruaz

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Francesco Marangoni

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Vladimir D. Vrbanac

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Edward Seung

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Ulrich H. von Andrian

    (Harvard Medical School)

  • Andrew M. Tager

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Andrew D. Luster

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

  • Thorsten R. Mempel

    (The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School)

Abstract

Using intravital microscopy, this study visualizes HIV-1-infected T cells within the lymph nodes of humanized mice, demonstrating that infected cells have reduced motility and long membrane processes; treating infected mice with a lymphocyte egress inhibitor prevents HIV-1 from spreading to the circulation during the course of treatment.

Suggested Citation

  • Thomas T. Murooka & Maud Deruaz & Francesco Marangoni & Vladimir D. Vrbanac & Edward Seung & Ulrich H. von Andrian & Andrew M. Tager & Andrew D. Luster & Thorsten R. Mempel, 2012. "HIV-infected T cells are migratory vehicles for viral dissemination," Nature, Nature, vol. 490(7419), pages 283-287, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7419:d:10.1038_nature11398
    DOI: 10.1038/nature11398
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    Cited by:

    1. Priscila C A da Silva & Tiago V Rosembach & Anésia A Santos & Márcio S Rocha & Marcelo L Martins, 2014. "Normal and Tumoral Melanocytes Exhibit q-Gaussian Random Search Patterns," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-13, September.
    2. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.

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