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Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

Author

Listed:
  • Jared H. Rowe

    (University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology)

  • James M. Ertelt

    (University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
    Present addresses: Cincinnati Children’s Hospital Medical Center, Division of Infectious Diseases, Cincinnati, Ohio 45229, USA (J.M.E., L.X. and S.S.W.).)

  • Lijun Xin

    (University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
    Present addresses: Cincinnati Children’s Hospital Medical Center, Division of Infectious Diseases, Cincinnati, Ohio 45229, USA (J.M.E., L.X. and S.S.W.).)

  • Sing Sing Way

    (University of Minnesota School of Medicine, Center for Infectious Disease and Microbiology Translational Research, Center for Immunology
    Present addresses: Cincinnati Children’s Hospital Medical Center, Division of Infectious Diseases, Cincinnati, Ohio 45229, USA (J.M.E., L.X. and S.S.W.).)

Abstract

Successful pregnancy requires immune tolerance against paternal antigens expressed by the fetus; here pregnancy is shown to stimulate the selective accumulation of maternal immune-suppressive regulatory T cells with fetal specificity that are retained post-partum, which may explain the protective benefits of prior pregnancy against pre-eclampsia and other complications in subsequent pregnancy.

Suggested Citation

  • Jared H. Rowe & James M. Ertelt & Lijun Xin & Sing Sing Way, 2012. "Pregnancy imprints regulatory memory that sustains anergy to fetal antigen," Nature, Nature, vol. 490(7418), pages 102-106, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7418:d:10.1038_nature11462
    DOI: 10.1038/nature11462
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