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Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

Author

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  • Norihiro Yumoto

    (Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA)

  • Natalie Kim

    (Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA)

  • Steven J. Burden

    (Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA)

Abstract

Lrp4 acts bidirectionally and coordinates synapse formation by binding agrin, activating MuSK and stimulating postsynaptic differentiation, and functioning in turn as a muscle-derived retrograde signal that is necessary and sufficient for presynaptic differentiation.

Suggested Citation

  • Norihiro Yumoto & Natalie Kim & Steven J. Burden, 2012. "Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses," Nature, Nature, vol. 489(7416), pages 438-442, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7416:d:10.1038_nature11348
    DOI: 10.1038/nature11348
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    Cited by:

    1. Rangjuan Cao & Peng Chen & Hongsheng Wang & Hongyang Jing & Hongsheng Zhang & Guanglin Xing & Bin Luo & Jinxiu Pan & Zheng Yu & Wen-Cheng Xiong & Lin Mei, 2023. "Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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