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Genome-wide association study indicates two novel resistance loci for severe malaria

Author

Listed:
  • Christian Timmann

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Thorsten Thye

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Maren Vens

    (Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Jennifer Evans

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Kumasi Centre for Collaborative Research in Tropical Medicine)

  • Jürgen May

    (Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Christa Ehmen

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Jürgen Sievertsen

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Birgit Muntau

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Gerd Ruge

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Wibke Loag

    (Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Daniel Ansong

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Sampson Antwi

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Emanuel Asafo-Adjei

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Samuel Blay Nguah

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Kingsley Osei Kwakye

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Alex Osei Yaw Akoto

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Justice Sylverken

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Michael Brendel

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Kathrin Schuldt

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Christina Loley

    (Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Andre Franke

    (Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany)

  • Christian G. Meyer

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

  • Tsiri Agbenyega

    (School of Medical Sciences, Kwame Nkrumah University of Science and Technology)

  • Andreas Ziegler

    (Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany)

  • Rolf D. Horstmann

    (Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany)

Abstract

A genome-wide association study in Ghana, West Africa, to identify genetic variants associated with malaria pathogenesis reveals two previously unknown loci on chromosomes 1 and 16.

Suggested Citation

  • Christian Timmann & Thorsten Thye & Maren Vens & Jennifer Evans & Jürgen May & Christa Ehmen & Jürgen Sievertsen & Birgit Muntau & Gerd Ruge & Wibke Loag & Daniel Ansong & Sampson Antwi & Emanuel Asaf, 2012. "Genome-wide association study indicates two novel resistance loci for severe malaria," Nature, Nature, vol. 489(7416), pages 443-446, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7416:d:10.1038_nature11334
    DOI: 10.1038/nature11334
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    Cited by:

    1. Alexandra Mirina & Gil Atzmon & Kenny Ye & Aviv Bergman, 2012. "Gene Size Matters," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-6, November.
    2. Gavin Band & Quang Si Le & Luke Jostins & Matti Pirinen & Katja Kivinen & Muminatou Jallow & Fatoumatta Sisay-Joof & Kalifa Bojang & Margaret Pinder & Giorgio Sirugo & David J Conway & Vysaul Nyirongo, 2013. "Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations," PLOS Genetics, Public Library of Science, vol. 9(5), pages 1-13, May.

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