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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

Author

Listed:
  • David Vilchez

    (Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Leah Boyer

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ianessa Morantte

    (Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Margaret Lutz

    (Stem Cell Core, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Carsten Merkwirth

    (Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Derek Joyce

    (Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Brian Spencer

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Lesley Page

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Eliezer Masliah

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • W. Travis Berggren

    (Stem Cell Core, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Andrew Dillin

    (Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Human embryonic stem cells (hESCs) are shown to have high 26S/30S proteasome activity owing to increased expression of the 19S proteasome subunit PSMD11; FOXO4 regulates proteasome activity in hESCs by modulating PSMD11 expression, and the high proteasome activity decreases after induced differentiation.

Suggested Citation

  • David Vilchez & Leah Boyer & Ianessa Morantte & Margaret Lutz & Carsten Merkwirth & Derek Joyce & Brian Spencer & Lesley Page & Eliezer Masliah & W. Travis Berggren & Fred H. Gage & Andrew Dillin, 2012. "Increased proteasome activity in human embryonic stem cells is regulated by PSMD11," Nature, Nature, vol. 489(7415), pages 304-308, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11468
    DOI: 10.1038/nature11468
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    Cited by:

    1. Laura Santini & Saskia Kowald & Luis Miguel Cerron-Alvan & Michelle Huth & Anna Philina Fabing & Giovanni Sestini & Nicolas Rivron & Martin Leeb, 2024. "FoxO transcription factors actuate the formative pluripotency specific gene expression programme," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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