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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Author

Listed:
  • Julie A. Mattison

    (Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103)

  • George S. Roth

    (GeroScience)

  • T. Mark Beasley

    (Ryals Public Health Bldg 343C University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, Alabama 35294, USA)

  • Edward M. Tilmont

    (Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103)

  • April M. Handy

    (Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103
    SoBran, Inc., 4000 Blackburn Lane, Suite 100, Burtonsville, Maryland 20866, USA)

  • Richard L. Herbert

    (National Institute of Allergy and Infectious Disease, NIH Animal Center, 16701 Elmer School Road, Building 102, Dickerson, Maryland 20842, USA)

  • Dan L. Longo

    (Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, 251 Bayview Boulevard Room 08C228, Baltimore, Maryland 21224, USA)

  • David B. Allison

    (Office of Energetics, University of Alabama at Birmingham, 1665 University Boulevard)

  • Jennifer E. Young

    (Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103)

  • Mark Bryant

    (Office of the Director, Diagnostic and Research Services Branch, NIH, Bldg 28A, Room 114, 28 Service Road West, Bethesda, Maryland 20814, USA)

  • Dennis Barnard

    (Office of the Director, Diagnostic and Research Services Branch, NIH, Building 14A, Room 119A, 14 Service Road West, Bethesda, Maryland 20814, USA)

  • Walter F. Ward

    (University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA)

  • Wenbo Qi

    (University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA)

  • Donald K. Ingram

    (Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA)

  • Rafael de Cabo

    (Laboratory of Experimental Gerontology, National Institute on Aging, NIH, 251 Bayview Boulevard Suite 100, Baltimore, Maryland 21224, USA)

Abstract

The results of a 23-year study of caloric restriction in rhesus macaques are reported; restricted caloric intake did not increase survival, but improved the metabolic profile of monkeys started at older ages and showed a trend towards delaying age-associated disease in monkeys started at a young age.

Suggested Citation

  • Julie A. Mattison & George S. Roth & T. Mark Beasley & Edward M. Tilmont & April M. Handy & Richard L. Herbert & Dan L. Longo & David B. Allison & Jennifer E. Young & Mark Bryant & Dennis Barnard & Wa, 2012. "Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study," Nature, Nature, vol. 489(7415), pages 318-321, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11432
    DOI: 10.1038/nature11432
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