IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v489y2012i7415d10.1038_nature11393.html
   My bibliography  Save this article

Distinct contribution of stem and progenitor cells to epidermal maintenance

Author

Listed:
  • Guilhem Mascré

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sophie Dekoninck

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Benjamin Drogat

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Khalil Kass Youssef

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Sylvain Brohée

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
    Université Libre de Bruxelles, Machine Learning Group, Brussels B-1050, Belgium)

  • Panagiota A. Sotiropoulou

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium)

  • Benjamin D. Simons

    (Cavendish Laboratory, J. J. Thomson Avenue, Cambridge CB3 0HE, UK
    The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Cédric Blanpain

    (Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
    WELBIO, Université Libre de Bruxelles, Brussels B-1070, Belgium)

Abstract

The skin interfollicular epidermis (IFE) is the first barrier against the external environment and its maintenance is critical for survival. Two seemingly opposite theories have been proposed to explain IFE homeostasis. One posits that IFE is maintained by long-lived slow-cycling stem cells that give rise to transit-amplifying cell progeny, whereas the other suggests that homeostasis is achieved by a single committed progenitor population that balances stochastic fate. Here we probe the cellular heterogeneity within the IFE using two different inducible Cre recombinase–oestrogen receptor constructs targeting IFE progenitors in mice. Quantitative analysis of clonal fate data and proliferation dynamics demonstrate the existence of two distinct proliferative cell compartments arranged in a hierarchy involving slow-cycling stem cells and committed progenitor cells. After wounding, only stem cells contribute substantially to the repair and long-term regeneration of the tissue, whereas committed progenitor cells make a limited contribution.

Suggested Citation

  • Guilhem Mascré & Sophie Dekoninck & Benjamin Drogat & Khalil Kass Youssef & Sylvain Brohée & Panagiota A. Sotiropoulou & Benjamin D. Simons & Cédric Blanpain, 2012. "Distinct contribution of stem and progenitor cells to epidermal maintenance," Nature, Nature, vol. 489(7415), pages 257-262, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11393
    DOI: 10.1038/nature11393
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11393
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11393?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11393. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.