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Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Author

Listed:
  • Marcus Dühren-von Minden

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Rudolf Übelhart

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
    Spemann Graduate School of Biology and Medicine, Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Dunja Schneider

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Thomas Wossning

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Martina P. Bach

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Maike Buchner

    (University Medical Center Freiburg, 79106 Freiburg, Germany)

  • Daniel Hofmann

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Elena Surova

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
    Spemann Graduate School of Biology and Medicine, Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Marie Follo

    (University Medical Center Freiburg, 79106 Freiburg, Germany)

  • Fabian Köhler

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany)

  • Hedda Wardemann

    (Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany)

  • Katja Zirlik

    (University Medical Center Freiburg, 79106 Freiburg, Germany)

  • Hendrik Veelken

    (Leiden University Medical Center, 2333 ZA Leiden, the Netherlands)

  • Hassan Jumaa

    (Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
    Faculty of Biology, Albert Ludwigs University of Freiburg and Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany)

Abstract

B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the binding of the BCR heavy-chain complementarity-determining region to self epitopes on the same receptor, a finding that may have important implications for understanding the pathogenesis of CLL and potential therapeutic approaches.

Suggested Citation

  • Marcus Dühren-von Minden & Rudolf Übelhart & Dunja Schneider & Thomas Wossning & Martina P. Bach & Maike Buchner & Daniel Hofmann & Elena Surova & Marie Follo & Fabian Köhler & Hedda Wardemann & Katja, 2012. "Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling," Nature, Nature, vol. 489(7415), pages 309-312, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7415:d:10.1038_nature11309
    DOI: 10.1038/nature11309
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    Cited by:

    1. Florian Märkl & Christoph Schultheiß & Murtaza Ali & Shih-Shih Chen & Marina Zintchenko & Lukas Egli & Juliane Mietz & Obinna Chijioke & Lisa Paschold & Sebastijan Spajic & Anne Holtermann & Janina Dö, 2024. "Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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