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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

Author

Listed:
  • Julie Zikherman

    (Rosalind Russell Medical Research Center for Arthritis, University of California)

  • Ramya Parameswaran

    (Rosalind Russell Medical Research Center for Arthritis, University of California)

  • Arthur Weiss

    (Rosalind Russell Medical Research Center for Arthritis, University of California
    Howard Hughes Medical Institute, University of California)

Abstract

Mature B cells encounter antigens during development that induce anergy or functional unresponsiveness; this large reservoir of dormant autoreactive B cells may serve as a pool of extended antibody specificity for purposes of protective immunity, as well as the source of pathogenic autoantibodies that characterize rheumatic diseases such as systemic lupus erythematosus.

Suggested Citation

  • Julie Zikherman & Ramya Parameswaran & Arthur Weiss, 2012. "Endogenous antigen tunes the responsiveness of naive B cells but not T cells," Nature, Nature, vol. 489(7414), pages 160-164, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7414:d:10.1038_nature11311
    DOI: 10.1038/nature11311
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    Cited by:

    1. Eileen Rauch & Timm Amendt & Aleksandra Lopez Krol & Fabian B. Lang & Vincent Linse & Michelle Hohmann & Ann-Christin Keim & Susanne Kreutzer & Kevin Kawengian & Malte Buchholz & Philipp Duschner & Sa, 2024. "T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Mikala JoAnn Simpson & Anna Minh Newen & Christopher McNees & Sukriti Sharma & Dylan Pfannenstiel & Thomas Moyer & David Stephany & Iyadh Douagi & Qiao Wang & Christian Thomas Mayer, 2024. "Peripheral apoptosis and limited clonal deletion during physiologic murine B lymphocyte development," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Sang Mun Han & Eun Seo Park & Jeu Park & Hahn Nahmgoong & Yoon Ha Choi & Jiyoung Oh & Kyung Min Yim & Won Taek Lee & Yun Kyung Lee & Yong Geun Jeon & Kyung Cheul Shin & Jin Young Huh & Sung Hee Choi &, 2023. "Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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