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The long-range interaction landscape of gene promoters

Author

Listed:
  • Amartya Sanyal

    (Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA)

  • Bryan R. Lajoie

    (Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA)

  • Gaurav Jain

    (Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA)

  • Job Dekker

    (Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA)

Abstract

Chromosome conformation capture carbon copy (5C) is used to look at the relationships between functional elements and distal target genes in 1% of the human genome in three dimensions; the study describes numerous long-range interactions between promoters and distal sites that include elements resembling enhancers, promoters and CTCF-bound sites, their genomic distribution and complex interactions.

Suggested Citation

  • Amartya Sanyal & Bryan R. Lajoie & Gaurav Jain & Job Dekker, 2012. "The long-range interaction landscape of gene promoters," Nature, Nature, vol. 489(7414), pages 109-113, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7414:d:10.1038_nature11279
    DOI: 10.1038/nature11279
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    Cited by:

    1. Victoria Honnell & Jackie L. Norrie & Anand G. Patel & Cody Ramirez & Jiakun Zhang & Yu-Hsuan Lai & Shibiao Wan & Michael A. Dyer, 2022. "Identification of a modular super-enhancer in murine retinal development," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Kathryn Weinand & Saori Sakaue & Aparna Nathan & Anna Helena Jonsson & Fan Zhang & Gerald F. M. Watts & Majd Al Suqri & Zhu Zhu & Deepak A. Rao & Jennifer H. Anolik & Michael B. Brenner & Laura T. Don, 2024. "The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    3. Milad Mokhtaridoost & Jordan J. Chalmers & Marzieh Soleimanpoor & Brandon J. McMurray & Daniella F. Lato & Son C. Nguyen & Viktoria Musienko & Joshua O. Nash & Sergio Espeso-Gil & Sameen Ahmed & Kate , 2024. "Inter-chromosomal contacts demarcate genome topology along a spatial gradient," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Ruitu Lyu & Yun Gao & Tong Wu & Chang Ye & Pingluan Wang & Chuan He, 2024. "Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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