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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Author

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  • Bon-Kyoung Koo

    (Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Maureen Spit

    (University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Ingrid Jordens

    (University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Teck Y. Low

    (Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
    The Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Daniel E. Stange

    (Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Marc van de Wetering

    (Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Johan H. van Es

    (Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Shabaz Mohammed

    (Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
    The Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Albert J. R. Heck

    (Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
    The Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Madelon M. Maurice

    (University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands)

  • Hans Clevers

    (Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

Abstract

In vivo and in vitro studies show that the stem-cell E3 ubiquitin ligases RNF43 and ZNRF3 act as tumour suppressors in colorectal cancer models, and are involved in the negative regulation of the cancer-associated Wnt signalling pathway through limiting the cell-surface expression of Wnt receptors.

Suggested Citation

  • Bon-Kyoung Koo & Maureen Spit & Ingrid Jordens & Teck Y. Low & Daniel E. Stange & Marc van de Wetering & Johan H. van Es & Shabaz Mohammed & Albert J. R. Heck & Madelon M. Maurice & Hans Clevers, 2012. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors," Nature, Nature, vol. 488(7413), pages 665-669, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11308
    DOI: 10.1038/nature11308
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    Citations

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    Cited by:

    1. Lishan Fang & Dane Ford-Roshon & Max Russo & Casey O’Brien & Xiaozhe Xiong & Carino Gurjao & Maximilien Grandclaudon & Srivatsan Raghavan & Steven M. Corsello & Steven A. Carr & Namrata D. Udeshi & Ja, 2022. "RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Szu-Hsien Sam Wu & Somi Kim & Heetak Lee & Ji-Hyun Lee & So-Yeon Park & Réka Bakonyi & Isaree Teriyapirom & Natalia Hallay & Sandra Pilat-Carotta & Hans-Christian Theussl & Jihoon Kim & Joo-Hyeon Lee , 2024. "Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Victoria H. Ng & Zachary Spencer & Leif R. Neitzel & Anmada Nayak & Matthew A. Loberg & Chen Shen & Sara N. Kassel & Heather K. Kroh & Zhenyi An & Christin C. Anthony & Jamal M. Bryant & Amanda Lawson, 2023. "The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Zachary T. Spencer & Victoria H. Ng & Hassina Benchabane & Ghalia Saad Siddiqui & Deepesh Duwadi & Ben Maines & Jamal M. Bryant & Anna Schwarzkopf & Kai Yuan & Sara N. Kassel & Anant Mishra & Ashley P, 2023. "The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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