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TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

Author

Listed:
  • Adam P. Gregory

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Calliope A. Dendrou

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Kathrine E. Attfield

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Aiden Haghikia

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    St. Josef-Hospital Bochum, Ruhr-University Bochum, 44791 Bochum, Germany)

  • Dionysia K. Xifara

    (Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, UK)

  • Falk Butter

    (Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany)

  • Gereon Poschmann

    (Molecular Proteomics Laboratory, Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine Universität Düsseldorf, D-40225 Düsseldorf, Germany)

  • Gurman Kaur

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Lydia Lambert

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Oliver A. Leach

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Simone Prömel

    (John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Divya Punwani

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • James H. Felce

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Simon J. Davis

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK)

  • Ralf Gold

    (St. Josef-Hospital Bochum, Ruhr-University Bochum, 44791 Bochum, Germany)

  • Finn C. Nielsen

    (Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark)

  • Richard M. Siegel

    (Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, 10 Center Drive)

  • Matthias Mann

    (Max-Planck-Institute of Biochemistry, D-82152 Martinsried, Germany)

  • John I. Bell

    (Richard Doll Building, Roosevelt Drive, University of Oxford, Oxford OX3 7DG, UK)

  • Gil McVean

    (Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, UK)

  • Lars Fugger

    (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Clinical Institute, Aarhus University Hospital, Skejby Sygehus, 8200 N Aarhus, Denmark)

Abstract

Genome-wide association studies in combination with functional analyses identify a genetic variant that explains why anti-tumour necrosis factor therapy, used in several autoimmune diseases, exacerbates multiple sclerosis.

Suggested Citation

  • Adam P. Gregory & Calliope A. Dendrou & Kathrine E. Attfield & Aiden Haghikia & Dionysia K. Xifara & Falk Butter & Gereon Poschmann & Gurman Kaur & Lydia Lambert & Oliver A. Leach & Simone Prömel & Di, 2012. "TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis," Nature, Nature, vol. 488(7412), pages 508-511, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11307
    DOI: 10.1038/nature11307
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    Cited by:

    1. Kensuke Yamaguchi & Kazuyoshi Ishigaki & Akari Suzuki & Yumi Tsuchida & Haruka Tsuchiya & Shuji Sumitomo & Yasuo Nagafuchi & Fuyuki Miya & Tatsuhiko Tsunoda & Hirofumi Shoda & Keishi Fujio & Kazuhiko , 2022. "Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Jiapei Yuan & Yang Tong & Le Wang & Xiaoxiao Yang & Xiaochuan Liu & Meng Shu & Zekun Li & Wen Jin & Chenchen Guan & Yuting Wang & Qiang Zhang & Yang Yang, 2024. "A compendium of genetic variations associated with promoter usage across 49 human tissues," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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