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Chromatin organization is a major influence on regional mutation rates in human cancer cells

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  • Benjamin Schuster-Böckler

    (EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain
    Pear Computer LLP, London W5 1SH, UK)

  • Ben Lehner

    (EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys, 23, Barcelona 08010, Spain)

Abstract

Mutation rates in cancer genomes are closely related to chromatin organization, indicating that the arrangement of the genome into heterochromatin- and euchromatin-like domains may be a dominant influence on variation in regional mutation rate in human somatic cells.

Suggested Citation

  • Benjamin Schuster-Böckler & Ben Lehner, 2012. "Chromatin organization is a major influence on regional mutation rates in human cancer cells," Nature, Nature, vol. 488(7412), pages 504-507, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11273
    DOI: 10.1038/nature11273
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    Cited by:

    1. Michael Habig & Cecile Lorrain & Alice Feurtey & Jovan Komluski & Eva H. Stukenbrock, 2021. "Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Andrey A. Yurchenko & Fatemeh Rajabi & Tirzah Braz-Petta & Hiva Fassihi & Alan Lehmann & Chikako Nishigori & Jinxin Wang & Ismael Padioleau & Konstantin Gunbin & Leonardo Panunzi & Fanny Morice-Picard, 2023. "Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Mischan Vali-Pour & Solip Park & Jose Espinosa-Carrasco & Daniel Ortiz-Martínez & Ben Lehner & Fran Supek, 2022. "The impact of rare germline variants on human somatic mutation processes," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    4. Clara Lopes Novo & Emily V. Wong & Colin Hockings & Chetan Poudel & Eleanor Sheekey & Meike Wiese & Hanneke Okkenhaug & Simon J. Boulton & Srinjan Basu & Simon Walker & Gabriele S. Kaminski Schierle &, 2022. "Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Luan Nguyen & Arne Hoeck & Edwin Cuppen, 2022. "Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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