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NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

Author

Listed:
  • Paras K. Anand

    (St. Jude Children’s Research Hospital)

  • R. K. Subbarao Malireddi

    (St. Jude Children’s Research Hospital)

  • John R. Lukens

    (St. Jude Children’s Research Hospital)

  • Peter Vogel

    (Animal Resources Center and the Veterinary Pathology Core, St. Jude Children’s Research Hospital)

  • John Bertin

    (Pattern Recognition Receptor DPU, Immuno-Inflammation TA, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA)

  • Mohamed Lamkanfi

    (Ghent University, B-9000 Ghent, Belgium
    VIB, B-9000 Ghent, Belgium)

  • Thirumala-Devi Kanneganti

    (St. Jude Children’s Research Hospital)

Abstract

The Nod-like receptor family member NLRP6 is characterized and shown to be a negative regulator of inflammatory signalling, dampening host responses against bacterial infections and impeding bacterial clearance.

Suggested Citation

  • Paras K. Anand & R. K. Subbarao Malireddi & John R. Lukens & Peter Vogel & John Bertin & Mohamed Lamkanfi & Thirumala-Devi Kanneganti, 2012. "NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens," Nature, Nature, vol. 488(7411), pages 389-393, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7411:d:10.1038_nature11250
    DOI: 10.1038/nature11250
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    Cited by:

    1. L. S. Tran & L. Ying & K. D’Costa & G. Wray-McCann & G. Kerr & L. Le & C. C. Allison & J. Ferrand & H. Chaudhry & J. Emery & A. De Paoli & N. Colon & S. Creed & M. Kaparakis-Liaskos & J. Como & J. K. , 2023. "NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Feng Zhi & Bowen Li & Chuanxia Zhang & Fan Xia & Rong Wang & Weihong Xie & Sihui Cai & Dawei Zhang & Ren Kong & Yiqiao Hu & Yilin Yang & Ya Peng & Jun Cui, 2023. "NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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