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Gut microbiota composition correlates with diet and health in the elderly

Author

Listed:
  • Marcus J. Claesson

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Ian B. Jeffery

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Susana Conde

    (University College Cork)

  • Susan E. Power

    (University College Cork)

  • Eibhlís M. O’Connor

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Siobhán Cusack

    (University College Cork)

  • Hugh M. B. Harris

    (University College Cork)

  • Mairead Coakley

    (Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland)

  • Bhuvaneswari Lakshminarayanan

    (Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland)

  • Orla O’Sullivan

    (Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland)

  • Gerald F. Fitzgerald

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Jennifer Deane

    (University College Cork)

  • Michael O’Connor

    (Cork University Hospital, Wilton, Cork, Ireland
    St. Finbarr’s Hospital, Douglas Road, Cork, Ireland)

  • Norma Harnedy

    (Cork University Hospital, Wilton, Cork, Ireland
    St. Finbarr’s Hospital, Douglas Road, Cork, Ireland)

  • Kieran O’Connor

    (St. Finbarr’s Hospital, Douglas Road, Cork, Ireland
    Mercy University Hospital, Grenville Place, Cork, Ireland
    South Infirmary, Victoria University Hospital)

  • Denis O’Mahony

    (Cork University Hospital, Wilton, Cork, Ireland
    St. Finbarr’s Hospital, Douglas Road, Cork, Ireland
    South Infirmary, Victoria University Hospital)

  • Douwe van Sinderen

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • Martina Wallace

    (Institute of Food and Health, University College Dublin)

  • Lorraine Brennan

    (Institute of Food and Health, University College Dublin)

  • Catherine Stanton

    (Alimentary Pharmabiotic Centre, University College Cork
    Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland)

  • Julian R. Marchesi

    (School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AT, UK)

  • Anthony P. Fitzgerald

    (University College Cork
    University College Cork)

  • Fergus Shanahan

    (Alimentary Pharmabiotic Centre, University College Cork
    University College Cork)

  • Colin Hill

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

  • R. Paul Ross

    (Alimentary Pharmabiotic Centre, University College Cork
    Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland)

  • Paul W. O’Toole

    (University College Cork
    Alimentary Pharmabiotic Centre, University College Cork)

Abstract

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

Suggested Citation

  • Marcus J. Claesson & Ian B. Jeffery & Susana Conde & Susan E. Power & Eibhlís M. O’Connor & Siobhán Cusack & Hugh M. B. Harris & Mairead Coakley & Bhuvaneswari Lakshminarayanan & Orla O’Sullivan & Ger, 2012. "Gut microbiota composition correlates with diet and health in the elderly," Nature, Nature, vol. 488(7410), pages 178-184, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7410:d:10.1038_nature11319
    DOI: 10.1038/nature11319
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    Cited by:

    1. Roger S. Fujioka & Helena M. Solo-Gabriele & Muruleedhara N. Byappanahalli & Marek Kirs, 2015. "U.S. Recreational Water Quality Criteria: A Vision for the Future," IJERPH, MDPI, vol. 12(7), pages 1-25, July.
    2. Aarthi Ravikrishnan & Indrik Wijaya & Eileen Png & Kern Rei Chng & Eliza Xin Pei Ho & Amanda Hui Qi Ng & Ahmad Nazri Mohamed Naim & Jean-Sebastien Gounot & Shou Ping Guan & Jasinda Lee Hanqing & Lihua, 2024. "Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.

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