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Protein activity regulation by conformational entropy

Author

Listed:
  • Shiou-Ru Tzeng

    (Rutgers University)

  • Charalampos G. Kalodimos

    (Rutgers University)

Abstract

Some variants of the bacterial gene regulator CAP show marked differences in their affinity for DNA despite identical DNA-binding interfaces; NMR spectroscopy experiments now show that DNA binding is determined by the proteins’ internal dynamics over a broad range of timescales in a manner that cannot be predicted from the proteins’ ground-state structures.

Suggested Citation

  • Shiou-Ru Tzeng & Charalampos G. Kalodimos, 2012. "Protein activity regulation by conformational entropy," Nature, Nature, vol. 488(7410), pages 236-240, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7410:d:10.1038_nature11271
    DOI: 10.1038/nature11271
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    Cited by:

    1. Tatu Pantsar & Sami Rissanen & Daniel Dauch & Tuomo Laitinen & Ilpo Vattulainen & Antti Poso, 2018. "Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling," PLOS Computational Biology, Public Library of Science, vol. 14(9), pages 1-23, September.
    2. Tek Narsingh Malla & Kara Zielinski & Luis Aldama & Sasa Bajt & Denisse Feliz & Brendon Hayes & Mark Hunter & Christopher Kupitz & Stella Lisova & Juraj Knoska & Jose Manuel Martin-Garcia & Valerio Ma, 2023. "Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Anna U Lowegard & Marcel S Frenkel & Graham T Holt & Jonathan D Jou & Adegoke A Ojewole & Bruce R Donald, 2020. "Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD:KRas protein-protein interface," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-27, June.

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