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Dissecting the genomic complexity underlying medulloblastoma

Author

Listed:
  • David T. W. Jones

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Natalie Jäger

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Marcel Kool

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Thomas Zichner

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Barbara Hutter

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Marc Sultan

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Yoon-Jae Cho

    (Stanford University, 750 Welch Road, Palo Alto, California 94304, USA.)

  • Trevor J. Pugh

    (Broad Institute of MIT and Harvard)

  • Volker Hovestadt

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Adrian M. Stütz

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Tobias Rausch

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Hans-Jörg Warnatz

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Marina Ryzhova

    (NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.)

  • Sebastian Bender

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Dominik Sturm

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Sabrina Pleier

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Huriye Cin

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Elke Pfaff

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Laura Sieber

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Andrea Wittmann

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Marc Remke

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Hendrik Witt

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.)

  • Sonja Hutter

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Theophilos Tzaridis

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Joachim Weischenfeldt

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Benjamin Raeder

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Meryem Avci

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Vyacheslav Amstislavskiy

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Marc Zapatka

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Ursula D. Weber

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Qi Wang

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Bärbel Lasitschka

    (Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Cynthia C. Bartholomae

    (German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.)

  • Manfred Schmidt

    (German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.)

  • Christof von Kalle

    (German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.)

  • Volker Ast

    (Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Chris Lawerenz

    (Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Jürgen Eils

    (Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Rolf Kabbe

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Vladimir Benes

    (Genomics Core Facility, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Peter van Sluis

    (AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.)

  • Jan Koster

    (AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.)

  • Richard Volckmann

    (AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands.)

  • David Shih

    (The Arthur and Sonia Labbatt Brain Tumor Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.)

  • Matthew J. Betts

    (Cell Networks Cluster of Excellence, University of Heidelberg)

  • Robert B. Russell

    (Cell Networks Cluster of Excellence, University of Heidelberg)

  • Simona Coco

    (IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, L.go R. Benzi,10, Genoa 16132, Italy.)

  • Gian Paolo Tonini

    (IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, L.go R. Benzi,10, Genoa 16132, Italy.)

  • Ulrich Schüller

    (Center for Neuropathology and Prion Research, University of Munich, Feodor-Lynen-Strasse 23, Munich 81377, Germany.)

  • Volkmar Hans

    (Institute for Neuropathology, Evangelisches Krankenhaus, Remterweg 2, Bielefeld 33617, Germany.)

  • Norbert Graf

    (Saarland University Hospital)

  • Yoo-Jin Kim

    (Institute for Pathology, Saarland University Hospital, Kirrberger Strasse)

  • Camelia Monoranu

    (Institute of Pathology, Würzburg University Josef-Schneider Strasse 2, Würzburg 97080, Germany.)

  • Wolfgang Roggendorf

    (Institute of Pathology, Würzburg University Josef-Schneider Strasse 2, Würzburg 97080, Germany.)

  • Andreas Unterberg

    (Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.)

  • Christel Herold-Mende

    (Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.)

  • Till Milde

    (Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Andreas E. Kulozik

    (Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.)

  • Andreas von Deimling

    (University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 220-221)

  • Olaf Witt

    (Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Eberhard Maass

    (Hematology & Immunology, Klinikum Stuttgart Olgahospital, Bismarckstrasse 8, Stuttgart 70176, Germany.)

  • Jochen Rössler

    (University Hospital Freiburg, Mathildenstrasse 1, Freiburg 79106, Germany.)

  • Martin Ebinger

    (Children’s University Hospital, Hoppe-Seyler Strasse 1, Tübingen 72076, Germany.)

  • Martin U. Schuhmann

    (University Hospital, Hoppe-Seyler Strasse 3)

  • Michael C. Frühwald

    (Children’s Hospital Augsburg, Stenglinstrasse 2)

  • Martin Hasselblatt

    (Institute of Neuropathology, University Hospital Münster, Albert-Schweitzer-Campus 1)

  • Nada Jabado

    (McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada.)

  • Stefan Rutkowski

    (University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.)

  • André O. von Bueren

    (University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany.)

  • Dan Williamson

    (Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle-upon-Tyne, NE1 4LP, UK.)

  • Steven C. Clifford

    (Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle-upon-Tyne, NE1 4LP, UK.)

  • Martin G. McCabe

    (School of Cancer and Enabling Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PL, UK.
    University of Cambridge, Cambridge CB2 0QQ, UK.)

  • V. Peter Collins

    (University of Cambridge, Cambridge CB2 0QQ, UK.)

  • Stephan Wolf

    (Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Stefan Wiemann

    (Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280)

  • Hans Lehrach

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Benedikt Brors

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

  • Wolfram Scheurlen

    (Cnopf’sche Kinderklinik, Nürnberg Children’s Hospital, St-Johannis-Mühlgasse 19)

  • Jörg Felsberg

    (Heinrich-Heine-University Düsseldorf, Moorenstrasse 5)

  • Guido Reifenberger

    (Heinrich-Heine-University Düsseldorf, Moorenstrasse 5)

  • Paul A. Northcott

    (The Arthur and Sonia Labbatt Brain Tumor Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.)

  • Michael D. Taylor

    (Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.)

  • Matthew Meyerson

    (Broad Institute of MIT and Harvard
    Dana Farber Cancer Institute, 450 Brookline Avenue)

  • Scott L. Pomeroy

    (Broad Institute of MIT and Harvard
    Children’s Hospital Boston, 300 Longwood Avenue)

  • Marie-Laure Yaspo

    (Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany.)

  • Jan O. Korbel

    (European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg 69117, Germany.)

  • Andrey Korshunov

    (University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany.
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 220-221)

  • Roland Eils

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg
    Bioquant Center, University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg 69120, Germany.)

  • Stefan M. Pfister

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
    Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.)

  • Peter Lichter

    (German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.)

Abstract

Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified.

Suggested Citation

  • David T. W. Jones & Natalie Jäger & Marcel Kool & Thomas Zichner & Barbara Hutter & Marc Sultan & Yoon-Jae Cho & Trevor J. Pugh & Volker Hovestadt & Adrian M. Stütz & Tobias Rausch & Hans-Jörg Warnatz, 2012. "Dissecting the genomic complexity underlying medulloblastoma," Nature, Nature, vol. 488(7409), pages 100-105, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7409:d:10.1038_nature11284
    DOI: 10.1038/nature11284
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    Cited by:

    1. Kakushadze, Zura & Yu, Willie, 2016. "Factor models for cancer signatures," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 462(C), pages 527-559.

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