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ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Author

Listed:
  • Tatsuo Hashimoto

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Yokohama City University Graduate School of Medicine and School of Medicine, 2360004 Yokohama, Japan)

  • Thomas Perlot

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Ateequr Rehman

    (Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany
    Present address: Department of Environmental Health Sciences, University Medical Center, Breisacher Strasse 115b, D-79106 Freiburg, Germany.)

  • Jean Trichereau

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Hiroaki Ishiguro

    (Yokohama City University Graduate School of Medicine and School of Medicine, 2360004 Yokohama, Japan)

  • Magdalena Paolino

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Verena Sigl

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Toshikatsu Hanada

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Reiko Hanada

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

  • Simone Lipinski

    (Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany)

  • Birgit Wild

    (Center of Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria)

  • Simone M. R. Camargo

    (Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland)

  • Dustin Singer

    (Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland)

  • Andreas Richter

    (Center of Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria)

  • Keiji Kuba

    (Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan)

  • Akiyoshi Fukamizu

    (Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan)

  • Stefan Schreiber

    (Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany)

  • Hans Clevers

    (Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands)

  • Francois Verrey

    (Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland)

  • Philip Rosenstiel

    (Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany)

  • Josef M. Penninger

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria)

Abstract

Mutations in angiotensin-converting enzyme 2 are shown to predispose mice to colitis as a consequence of neutral amino acid malabsorption and a change in the resident microbiota; these results could explain how protein malnutrition — affecting up to one billion people — leads to intestinal inflammation.

Suggested Citation

  • Tatsuo Hashimoto & Thomas Perlot & Ateequr Rehman & Jean Trichereau & Hiroaki Ishiguro & Magdalena Paolino & Verena Sigl & Toshikatsu Hanada & Reiko Hanada & Simone Lipinski & Birgit Wild & Simone M. , 2012. "ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation," Nature, Nature, vol. 487(7408), pages 477-481, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11228
    DOI: 10.1038/nature11228
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    Cited by:

    1. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yan-Xin Zhang & Xin Yang & Pan Zou & Peng-Fei Du & Jing Wang & Fen Jin & Mao-Jun Jin & Yong-Xin She, 2016. "Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy through HPLC-QTOF-MS," IJERPH, MDPI, vol. 13(5), pages 1-17, May.
    3. Mouna Chajadine & Ludivine Laurans & Tobias Radecke & Nirmala Mouttoulingam & Rida Al-Rifai & Emilie Bacquer & Clara Delaroque & Héloïse Rytter & Marius Bredon & Camille Knosp & José Vilar & Coralie F, 2024. "Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Guanlan Hu & Catriona Ling & Lijun Chi & Mehakpreet K. Thind & Samuel Furse & Albert Koulman & Jonathan R. Swann & Dorothy Lee & Marjolein M. Calon & Celine Bourdon & Christian J. Versloot & Barbara M, 2022. "The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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