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RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

Author

Listed:
  • Min Yu

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
    Howard Hughes Medical Institute)

  • David T. Ting

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Shannon L. Stott

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Ben S. Wittner

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Fatih Ozsolak

    (Helicos BioSciences Corporation, One Kendall Square)

  • Suchismita Paul

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Jordan C. Ciciliano

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Malgorzata E. Smas

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Daniel Winokur

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Anna J. Gilman

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Matthew J. Ulman

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Kristina Xega

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Gianmarco Contino

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Brinda Alagesan

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Brian W. Brannigan

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Patrice M. Milos

    (Helicos BioSciences Corporation, One Kendall Square)

  • David P. Ryan

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Lecia V. Sequist

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Nabeel Bardeesy

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Sridhar Ramaswamy

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Mehmet Toner

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Shyamala Maheswaran

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School)

  • Daniel A. Haber

    (Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
    Howard Hughes Medical Institute)

Abstract

A new method allows the collection of circulating tumour cells (CTCs) despite their rarity; transcriptome sequencing of CTCs could allow identification of pathways involved in metastasis.

Suggested Citation

  • Min Yu & David T. Ting & Shannon L. Stott & Ben S. Wittner & Fatih Ozsolak & Suchismita Paul & Jordan C. Ciciliano & Malgorzata E. Smas & Daniel Winokur & Anna J. Gilman & Matthew J. Ulman & Kristina , 2012. "RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis," Nature, Nature, vol. 487(7408), pages 510-513, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11217
    DOI: 10.1038/nature11217
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