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SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

Author

Listed:
  • Marco Montagner

    (University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy)

  • Elena Enzo

    (University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy)

  • Mattia Forcato

    (Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy)

  • Francesca Zanconato

    (University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy)

  • Anna Parenti

    (Section of Pathology, University of Padua, Viale Gabelli 2, 35126 Padua, Italy)

  • Elena Rampazzo

    (Clinical and Experimental Hematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy)

  • Giuseppe Basso

    (Clinical and Experimental Hematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy)

  • Genesio Leo

    (Hospital San Bassiano, Via dei Lotti 40, 36061 Bassano del Grappa, Italy)

  • Antonio Rosato

    (Oncology and Gastroenterology, and Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35126 Padua, Italy)

  • Silvio Bicciato

    (Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy)

  • Michelangelo Cordenonsi

    (University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy)

  • Stefano Piccolo

    (University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy)

Abstract

SHARP1, which is itself regulated by the p63 metastasis suppressor, regulates the invasive and metastatic phenotype in triple-negative breast cancer (TNBC) through inhibition of hypoxia-inducible factors, and this process operates independently from oxygen levels.

Suggested Citation

  • Marco Montagner & Elena Enzo & Mattia Forcato & Francesca Zanconato & Anna Parenti & Elena Rampazzo & Giuseppe Basso & Genesio Leo & Antonio Rosato & Silvio Bicciato & Michelangelo Cordenonsi & Stefan, 2012. "SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors," Nature, Nature, vol. 487(7407), pages 380-384, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7407:d:10.1038_nature11207
    DOI: 10.1038/nature11207
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    Cited by:

    1. Jiang-jiang Li & Tiantian Yu & Peiting Zeng & Jingyu Tian & Panpan Liu & Shuang Qiao & Shijun Wen & Yumin Hu & Qiao Liu & Wenhua Lu & Hui Zhang & Peng Huang, 2024. "Wild-type IDH2 is a therapeutic target for triple-negative breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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